The 99% purity threshold supports reproducibility in sensitive in-vitro and pre-clinical work
Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist
The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]
Better Brain Function: B12 is important for maintaining healthy nerve cells and is involved in neurotransmitter signaling
The compound's primary target, NNMT, sits at a critical metabolic intersection where NAD+ precursor availability meets cellular methylation capacity
It is important to stress that insufficient levels of B12 raise susceptibility to infections and diseases, and are very harmful to the nervous system which in turn can cause neurological disorders and severe and sometimes irreversible nerve damage
